CAD and Platelet Dysfunction
Introduction[edit | edit source]
Treatment of Acute Coronary Syndrome (ACS) involves many of the platelet modulating drugs such as Aspirin, GPIIb/IIIa inhibitors.
Primary Prevention of Coronary Artery Disease includes Aspirin. Secondary Prevention of CAD includes Aspirin.
Though the current models for atherosclerosis does not revolve around platelet abnormalities: the question raised here is: 1. Are there any platelet speicific pathophysiology that predispose one to have ACS. 2. Are there any interventions (other than Aspirin) that are specifically related to platelets for primary/secondary prevention.
We will first review: 1. Platelet physiology 2. Atherosclerosis physiology